#1. Alpha-lipoic acid, a coenzyme of pyruvate and alpha-ketoglutarate dehydrogenase, has been used in Germany as an . (Lipoic acid can sometimes impede the body's removal of copper. Chelating with amalgam leftovers can result in a mobilization and redistribution of mercury into the Central Nervous System. These qualities allow alpha lipoic acid benefits to extend to a wide range of health issues and conditions. Alpha-lipoic acid is an antioxidant also known as Acetate Replacing Factor, ALA, Biletan, Lipoicin, Thioctan, and many other names. These side effects can include upset stomach, nausea, diarrhea, flatulence and the likes. It is found in every cell, where it helps turn glucose into energy. Alpha lipoic acid helps to increase ATP production which isn't just beneficial in reducing fatigue but also helps to increase the cellular . . Reed LJ. Originally ALA was thought to be a vitamin, but then it was discovered that the human body produces it on its own. on Low Dose Naltrexone and Alpha Lipoic Acid, September 18, 2018 About One Radio In another study, lipoic acid can significantly help improve some types of scars. Mercury is initially distributed by the circulatory system and enters nerve endings and travels the central nervous system using a mechanism known as retrograde axonal transport leaving a path of destruction. If there are any side-effects monitor these and if too intense, stop, wait a few days and start on a lower dose, such as 10mg or 6mg. Detoxing The Brain With Alpha-Lipoic Acid. Reply. It when ALA grabs Mercury from one location and drops is after its half life. The decline one experiences by taking ALA with mercury in one's teeth is slow. ( Wikipedia) This graphic demonstrates the outcomes of both proper and improper use use of alpha lipoic acid. This article is being expanded over time. Alpha lipoic acid is also known as the universal antioxidant. This article is being expanded over time. March 21, 2021 at 4:33 pm. Supposedly, if you don't, you risk just moving the mercury around from one place in the body to another, just doing more damage. ALA is a natural substance, produced in . People who have chronic fatigue syndrome are not advised to use alpha lipoic acid supplements as a substitute or as only medication for medical care. In one study, Alpha Lipoic Acid has a high potential to reduce wrinkles and fine lines in the skin by up to 50 percent. Now we're getting to more powerful detox supplements. At the same time, ALA is a supplement used by probably millions of people for neuropathy and as an antioxidant. But Andy talks about "bouncing mercury around" and is that redistribution or not? Alpha-lipoic acid is an antioxidant derived from caprylic acid. It is an organic sulfur compound made up of left and right components. Research has attempted to identify the role of antioxidants, glutathione and alpha-lipoic acid specifically, in both mitigation of heavy metal toxicity and . Along with selenium, ALA will help us deal with mercury that is polluting the body. 2001;276(42):38329-38336. This is where energy (ATP) is produced. Alpha-lipoic acid is an antioxidant that is made naturally in the body and also found in foods. -- in other words "other" kinds of problems. Improves several components of the metabolic syndrome—a combination of risk factors that increases one's risk for diabetes 6. Subject: Re: Alpha Lipoic Acid as an antioxidant; Date: Fri, 16 Jul 2004 07:20:24 -0000; Yahoo! Detoxing The Brain With Alpha-Lipoic Acid. Because it acts like an antidote to oxidative stress and inflammation, alpha lipoic acid seems to fight damage done to the blood vessels, brain, neurons and organs, like the heart or liver. Quick Gist: Alpha lipoic acid's antioxidant action helps protect nerve health from toxicity and supports recovery from nerve injury. The experiments showed that alpha lipoic acid dramatically increased the excretion of Hg++ into bile. Improves the lipid profile. The results would be redistribution and chronic sickness. The metal chelator meso-2,3-dimercaptosuccinic acid (DMSA) is considerably less toxic than the classical agent . I'm reducing my dose drastically because the BMS pain is so bad and I'm searching for relief. Alpha-Lipoic acid also balances blood glucose levels and increases insulin sensitivity, which can help manage diabetes while also assisting the body in promoting weight loss. J Biol Chem. The antioxidant property of ALA explains its protective action in diabetic and chemotherapy-induced neuropathy. Higher doses of alpha lipoic acid in healthy person can result in fatigue or upset stomach. It helps mitochondria make more energy. . LA contains two sulfur atoms (at C6 and C8) connected by a disulfide bond and is thus considered to be oxidized although either sulfur atom can exist in higher oxidation states. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systemic review and meta-analysis of randomized controlled trials . Below are a handful of its beneficial effects. Messages. ALA is supposed to mobilize mercury from the places it gets sequestered, which is why you need to maintain a constant dose of ALA while you're taking it, and until the mercury is eliminated. Upon oxidation with reactive oxygen species (ROS) and pro-oxidants, α-LA may be reconstituted from DHLA and other reduced forms. After a 7-day equilibrium period, DMPS, DMSA, GSH, vitamin C, lipoic acid alone, or in combination was administered for 7 days and the brain and kidneys of the animals removed and analyzed for mercury by cold vapor atomic absorption. Magis D, Ambrosini A, Sandor P, Jacquy J, Laloux P, Schoenen J. Again, that is a monster dose for some people. One serving of it (the NLEA serving size of 148 grams) provides 4.2 grams of protein and only 50 calories. 3. alpha lipoic acid @ 100 - 200 mg daily 4. udo's senior-specific probiotic (i bought the wrong one..) @ 1x daily 5. nordic naturals ultimate omega @ 900 MG DHA daily/1,300 MG EPA 6. solaray multi-mineral @ 1x daily, most of the minerals are at 100% RDA 7. solaray bio-magnesium citrate @ 100% RDA, before bed 8. rhodiola force 300 mg @ 1x daily The theorists reasoned that if mercury was the cause of autism, then removing mercury from the body would cure autism. It's needed by the body to produce the energy for our body's normal functions. . Lipoic acid | C8H14O2S2 | CID 6112 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more. It is very important that Alpha Lipoic Acid or any chelator is taken on its half-life rather than randomly. Alpha Lipoic Acid is involved in aerobic metabolism, such as breathing. Since reading some about it here and in an article where Peat mentions that Lipoic . Pharmacol Res. Sulfur-containing compounds can complex with heavy metals, and the sulfur antioxidants alpha-lipoic acid (ALA) and glutathione have been demonstrated to chelate a number of metals in cell culture (mercury for glutathione; cadmium, lead, zinc, cobalt, nickel, iron, and copper for ALA) (Patrick 2002). Brussel sprouts are also high protein. Alpha-lipoic acid is a naturally occurring fatty acid that can . Mercury is highly neurophilic (strong affinity for nervous tissue) and highly lipophilic (binds tightly to fatty tissue). Alpha-lipoic acid, a coenzyme of pyruvate and alpha-ketoglutarate dehydrogenase, has been used in Germany as an antioxidant and approved treatment for diabetic polyneuropathy for 40 years. Alpha-Lipoic Acid Alpha-Lipoic Acid Alpha-Lipoic Acid 90 veggie capsules - $15.95 Alpha-lipoic acid is equally important for it will, along with selenium, raise glutathione levels. In particular, it can reach the mercury in your brain and nerve tissue. They seem to reduce symptoms like pain, tingling, and . Years ago (before I knew about mercury poisoning, let alone that I had been poisoned by the "harmless" amalgams) I took one tablet of supposedly wonderful ala. Alpha Lipoic Acid (ALA, thioctic acid, pyruvate oxidation factor) was first discovered by bacteriologist Irwin C. Gunsalus in 1948 when he observed that aerobic (oxygen-requiring) bacteria could not grow without it. Being low in antioxidants in general can speed up in the aging process, resulting in . These absolutely should not be taken unless all amalgam fillings have been removed. . Aug 24, 2013. Alpha-lipoic acid, a coenzyme of pyruvate and alpha-ketoglutarate dehydrogenase, has been used in Germany as an antioxidant and approved treatment for diabetic polyneuropathy for 40 years. Toniq is a major name when it comes to both purity and potency. I agree that mobilizing the mercury with either Cilantro or ALA (alpha lipoic acid) can lead to redistribution into the CNS with high dose . Currently, very few commercially available pharmaceuticals can successfully reduce or prevent the toxicity of these metals. Alpha-Lipoic Acid and Glutathione. When taken at recommended doses, there are no harmful side effects to be expected. It was part of a heavy metals cleanse which included a lot of herbs and stuff. Its chemical name is 1,2-dithiolane-3-pentanoic acid or thioctic acid. It temporarily alleviated some moderate insomnia. 24. Reply. These absolutely should not be taken unless all amalgam fillings have been removed. If it is not safe because of this, should anyone be taking it at all? This ALA is encapsulated in vegetarian capsules and is highly bioavailable. Alpha Lipoic Acid and Liver Disease. Antioxidants attack "free radicals," waste products created when the body turns food into energy. Shade theorizes that the observed increase of Hg++ in bile is the result of alpha lipoic acid . The health benefits of alpha lipoic acid include supporting conditions such as: Multiple sclerosis. Excessive intake of ALA can lead to the lowering of blood sugar. Alpha Lipoic Acid have benefit for skin cells and improve skin texture and wrinkles. ALA chelates intra-cellular mercury, but it can also redistribute it. RESULTS:None of these regimens reduced the mercury content of the brain. Download. - posted in Supplements: Is it safe to take alpha lipoic acid given that it can redistribute mercury around the body? Later, Gunsalus and Lester Reed determined the true structure and named it ALA (1951). skin rash. Andy Cutler warns against supplementing with ALA irregularly for the risk of mercury redistribution in the brain and organs. Alpha lipoic acid (α-LA) and its reduced form dihydrolipoic acid (DHLA) have been historically considered as excellent anti-oxidants and oxidative stress scavengers. 2) Alpha-Lipoic Acid. National Institutes of Health. 3. Alpha Lipoic Acid (ALA) is also known as Lipoic Acid or Thiotic Acid. Free radicals cause harmful chemical reactions that can damage cells, making it harder for the body to fight off infections. Reduces insulin resistance. It is involved in a variety of reactions, such as the conversion of pyruvate and other alpha-keto acids in the Krebs cycle. This bottle of high-strength ALA contains 120 capsules of 99% alpha-lipoic acid, each containing 500 mg, for $18.97. After a month the pain was still present and my stomach was bloated. These radicals can destroy healthy cells and affect cell aging, rendering alpha-lipoic acid . But Andy talks about "bouncing mercury around" and is that redistribution or not? a light-headed feeling, like you might pass out. I take HM CHELATE by 'Pure Encaspulation'- it's FOR the purpose of removing metals and it contains alpha lipoic acid, chlorella, cilantro, l-methionine, NAC, zinc, selenium, and some other citrus derivatives. People should therefore take care when using certain detoxification substances and always follow. So make sure you are not copper poisoned before trying the lipoic acid.) Alpha-lipoic acid, a coenzyme of pyruvate and alpha-ketoglutarate dehydrogenase, has been used in Germany as an antioxidant and approved treatment for diabetic polyneuropathy for 40 years. It is an organosulfur compound and is produced in the body of humans and animals. It can support healthy blood sugars and decrease A1C levels. Broccoli has more protein than steak. In addition, research suggests. . Its production occurs from octanoic acid and cysteine as . every 3 hours. Because it acts like an antidote to oxidative stress and inflammation, alpha lipoic acid seems to fight damage done to the blood vessels, brain, neurons and organs, like the heart or liver. Still, Dr. Perlmutter mentions that ALA is a metal chelator. On a per calorie basis, broccoli actually contains more protein than steak. Side effects only start to be felt at higher doses. It enables the mercury to flood into your brain. A trail of research from lipoic acid to alpha-keto acid dehydrogenase complexes. Scientists are researching whether it can bind to heavy metals in the brain and reduce damage to cellular membranes [34, 35, 36]. Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid naturally found in your body. Answer (1 of 2): It is very harmful. By Burt Berkson MD PhD. ALA's ability to fight oxidative stress is many times more potent . ALA Benefits. I don't remember exactly why, but I most certainly . 1999 Jan;39(1):67-80. Alpha-Lipoic Acid is a powerful antioxidant and is know to expel mercury from the brain. Keeping a steady state level of alpha lipoic acid in the bloodstream will minimize redistribution of mercury into the central nervous system, but it is quite inconvenient and difficult to perform. Has Anti-Inflammatory and Antioxidant Effects. Shop Toniq Alpha Lipoic Acid on Amazon. ALA - ALPHA LIPOIC ACID (Also known as LIPOIC ACID or THIOCTIC ACID) . Lipoic acid (LA), also known as α-lipoic acid, alpha-lipoic acid (ALA) and thioctic acid, is an organosulfur compound derived from caprylic acid (octanoic acid). Improper use is what leads pushes mercury into the brain and nervous system causing many of the symptoms you will read in the testimonials below. Subject: ALA and redistribution of mercury; Date: Sat, 28 Jun 2003 16:00:19 -0000; Yahoo! Reduces blood pressure. Related Papers. At the lowest lipoic acid dose there was a 12-fold increase of Hg++ excretion while at the largest dose, a 40-fold increase in Hg++ was found in bile. . R-lipoic acid 50mg Coenzyme Q10 50mg chromium picolinate 65 µg magnesium citrate 37.5mg sodium selenite 50 µg sodium molybdate 15 µg manganese citrate 0.8mg cupric citrate 0.5 mg zinc citrate D-biotin 75 µg b12 dibencozide 3 µg + methylcobalamin 3 µg calcium folate L-methylfolate 150 µg b5 calcium pantothenate 4mg b6 pyridoxal-5 . Reduces oxidative stress in the body via powerful antioxidant activity 1,3-5. Common side effects may include: nausea; or. [i] ALA (alpha lipoic acid) is an enzyme found throughout the body and a key component of mitochondria, which produce energy for cells. Alpha lipoic acid can relieve nerve pain in peripheral neuropathy. Subject: ALA and redistribution of mercury; Date: Sat, 28 Jun 2003 16:00:19 -0000; Yahoo! Thus, it is hard for patients and doctors to see the cause and effect. From WebMD: Alpha-lipoic acid (ALA) . Health Benefits. ALA, it is considered to be a universal and unique anti-oxidant because it is both fat and water soluble. No clinical trial has examined the use of lipoic acid as a chelating agent in mercury toxicity, yet it has proven to be effective in several mammalian species . Subject: Re: Alpha Lipoic Acid as an antioxidant; Date: Fri, 16 Jul 2004 07:20:24 -0000; Yahoo! March 21, 2021 at 4:33 pm. . Alpha-lipoic acid can be eaten in foods,. It's called "redistribution". Vigil M, Berkson BM, Garcia AP, Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria. Being low in antioxidants in general can speed up in the aging process, resulting in . Removing the Toxic Sources First David Tomen says. David Tomen says. Here are 8 little known benefits of alpha lipoic acid (ALA): 1. Chelating with the Andrew Cutler Protocol involves the following three chelators: ALA (Alpha Lipoic Acid), half life: 3 hours Diabetes. Because of its two sulfurs, ALA can bind and transport mercury for excretion from the body. term lasting problems are due to mercury redistribution. If you aren' t mercury or copper poisoned, then 300 mg per day appears safe. . I agree that mobilizing the mercury with either Cilantro or ALA (alpha lipoic acid) can lead to redistribution into the CNS with high dose . Higher doses of ALA may result in increased heart palpitation, which in turn may cause fatigue. Now we're getting to more powerful detox supplements. Both fat and water soluble, it is readily absorbed from the gut and crosses cellular and blood-brain membrane barriers [ 22, 53 ]. Anti-oxidant: Alpha lipoic acid serves to recycle other anti-oxidants like Vitamin E and Vitamin C. Whereas the latter work in either If your detoxification systems (e.g., GSH, CYP-450) are subpar, you might be getting some redistribution from 50mg. Alpha-Lipoic Acid is a powerful antioxidant and is know to expel mercury from the brain. Antioxidants are important because they can help minimize cell damage that is caused by excessive production of harmful free radicals. All of the physical effects from Alpha-Lipoic acid can be traced back to its work in the brain. ALA Benefits. 1. A harmful chelation protocol is one that causes preferential redistribution of mercury from less sensitive to more sensitive locations in the body. It's the Universal Antioxidant. Alpha-lipoic acid is a powerful supplement you can use to help prevent oxidative stress. The nutrient ALA (alpha lipoic acid) is a dithiol (with 2 sulfur atoms) compound that is normally used by the body in small amounts as part of the enzymes for producing cellular energy. Because it acts like an antidote to oxidative stress and inflammation, alpha lipoic acid seems to fight damage done to the blood vessels, brain, neurons, and organs like the heart or liver. National Center for Biotechnology Information. The first time I ever used alpha Lipoic acid was in 2009, way before ever discovering Dr Peat's work. ALA is a potent antioxidant and regenerates other antioxidants. Needless to say, I was very constipated. Lipoic acid pulls mercury out of your tissue. It begins as an anti-oxidant which can lower lipid peroxides, continues as a metal detoxifier, acts as a mitochondrial enhancer, and serves to recycle glutathione. . Alpha-lipoic acid 600mg helps in the regeneration of antioxidants such as Vitamins E and C and glutathione in the body. Keeping a steady state level of alpha lipoic acid in the bloodstream will minimize redistribution of mercury into the central nervous system, but it is quite inconvenient and difficult to perform. antioxidant protection in the prevention of neurological and renal damage caused by mercury toxicity. Alpha lipoic acid, mercury redistribution, and safety concerns. Alpha lipoic acid is another supplement with multiple benefits. (ii) Alpha lipoic acid is a powerful antioxidant that regenerates other antioxidants (e.g., vitamins E and C, and reduced glutathione) and has metal-chelating activity. Maybe cut the dose in half and see if you get the same benefits without the downside. Alpha lipoic acid (also known as dihydrolipoic acid, lipoic acid, lipolate or thiotic acid) Cysteine (also called acetylcysteine, cystein, cystin, L-cysteine, N-acetylcysteine, or NAC) Alpha lipoic acid is a compound found naturally inside every cell in the body. For example EDTA is a poor chelator for Mercury (but great for Lead), therefore if you have a lot of Mercury, do not start with EDTA. If you have a source of that heavy metal in the body - as you do with "silver" fillings - one should be able to deduce that the . Your blood levels of your chelator will have dropped too much with the late dose inducing a lot of redistribution of mercury. . To put it simply, mercury in the brain, liver, thyroid, adrenal glands and immune system cells will cause more serious damage because these organs and systems are sensitive. 1. A randomized double-blind placebo-controlled trial of thioctic acid in migraine . Andy Cutler warns against supplementing with ALA irregularly for the risk of mercury redistribution in the brain and organs. Alpha lipoic acid is one of the key mitochondrial antioxidants, mitochondria are found in all cells of the body and known as the 'energy centres' of the cell. ALA also has been proven to chelate, or bind, to toxic metals . It has the ability to scavenge free radicals in a very efficient manner and also enhances the production of glutathione. The Side Effects of Alpha Lipoic Acid. Alpha-lipoic acid: Alpha-lipoic acid is a strong antioxidant that can renew other antioxidants in the body and chelate metals from the body. The present article reviews the clinical use of thiol-based metal chelators in intoxications and overexposure with mercury (Hg), cadmium (Cd), and lead (Pb). It is also a potent antioxidant that has been used to treat a variety of conditions, including diabetes, AIDS, cancer, hypertension . DMSA, DMPS and ALA (Alpha-Lipoic Acid) are good for Mercury, but see below about ALA and brain blood barrier. Alpha-lipoic acid, a coenzyme of pyruvate and alpha-ketoglutarate dehydrogenase, has been used in Germany as an . It is used to break down carbohydrates and to make energy. Anuradha B, Varalakshmi P. Protective role of DL-alpha-lipoic acid against mercury-induced neural lipid peroxidation. A significant portion of the country has amalgam fillings. National Library of Medicine. 649. ALA is made in animals normally, and is essential for aerobic metabolism.It is also manufactured and is available as a dietary supplement in some countries where it is marketed as an antioxidant, and is available as a pharmaceutical . Alpha-lipoic acid (ALA) is another antioxidant that is hypothesized to have the ability to penetrate the cell membrane as well as cross the blood-brain barrier. Adverse Effects of High Doses of Intravenous Alpha Lipoic Acid on Liver Mitochondria. Certain chelators, such as alpha-lipoic acid, can cause the redistribution of metals in the body. This mean it offers numerous benefits throughout the whole body, from naturally treating Alzheimer's disease to controlling liver disease. term lasting problems are due to mercury redistribution. The cells in our body are . Research has attempted to identify the role of antioxidants, glutathione and alpha-lipoic acid specifically, in both mitigation of heavy metal toxicity and . Please, ask your dentist for bite-wing x-rays to verify that you are truly amalgam free. Alpha-lipoic acid is an antioxidant made by the body. Studies also found that alpha-lipoic acid supplements can help with neuropathy -- nerve damage -- caused by diabetes or cancer treatment. One cup (38 calories worth) provides 3 grams of protein. -- in other words "other" kinds of problems. Alpha lipoic acid is a substance that neutralizes potentially harmful chemicals called free radicals. Some people with mercury fillings claim that they had a major mercury and arsenic redistribution that effected their health when they took ALA. Dr. Burt Berkson, PhD, M.D. Stop taking alpha-lipoic acid and call your doctor at once if you have: low blood sugar-- headache, hunger, weakness, sweating, confusion, irritability, dizziness, fast heart rate, or feeling jittery; or. Alpha Lipoic Acid (ALA) is a mercury-chelating antioxidant. Toniiq Alpha Lipoic Acid. Selenium: Selenium may help remove mercury from the body. Its other names are ALA, lipoic acid, Biletan, Lipoicin, Thioctan, etc. Alpha-Lipoic-Acid-300 (alpha-lipoic acid) for Dietary Supplementation: "I took a total of 400-600 mgs daily for burning mouth syndrome. Alpha-Lipoic Acid (ALA) is a sulfur-containing fatty acid naturally found in your body. Has Anti-Inflammatory and Antioxidant Effects. antioxidant protection in the prevention of neurological and renal damage caused by mercury toxicity. Glutathione is one of the main antioxidants your body naturally produces. PubChem . Lipoic acid (LA), also known as α-lipoic acid [2], alpha lipoic acid (ALA) and thioctic acid [3] is an organosulfur compound derived from octanoic acid. Alpha lipoic acid supplementation shows great promise in boosting memory, lowering blood sugar, and keeping free radical damage at bay.
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